Molecular Rapid Aneuploidy (in collaboration wtih UK NEQAS for Molecular Genetics)|
Accredited UKAS 7872.
Molecular Rapid Aneuploidy testing (QF-PCR/MLPA/BoBs). Note: This EQA is not suitable for NIPT technology.
PURPOSE OF PROGRAMME:
to establish the analytical and interpretative capabilities of the participating laboratory using rapid molecular prenatal techniques.
MATERIAL PROVIDED: DNA.
DISTRIBUTIONS PER YEAR: 1
SAMPLES PER DISTRIBUTION: 3 cases
FREQUENCY OF DISTRIBUTION: 1 distribution in accordance with the annual EQA timetable, offered in collaboration with UK NEQAS for Molecular Genetics.
PROGRAMME OF ANALYSIS:
DNA samples are sent to the laboratory, each with a case scenario to mimic a routine diagnostic case. QF-PCR or MLPA or BoBs methodology can be used according to routine diagnostic practice. This EQA is not suitable for NIPT technology. Instructions and a user guide are available on the website. The participant analyses the sample, interprets the results and reports via the CEQAS website. The EQA is open for 4 weeks. Results can be entered at any time during this period. Any non-submitting labs
All EQA cases are validated prior to release. Results are assessed by a panel of experts against set marking criteria based upon professional guidelines. There are three marking categories, Analytical, Interpretation and Clerical Accuracy. Each category carries two points. Deductions are made in accordance with the severity of the omission. A “critical error” is an error made in either the analytical or interpretive category that could lead to serious clinical consequences or imply a significa
Satisfactory/Poor. A non-submission is also given a poor performance.
PERSISTENT POOR PERFORMANCE:
This is defined as: a) Two poor performances in any MRA EQA in which the laboratory participates, over three or more distributions of material, within a 36 month rolling period; b) A poor performance within one year following a previous persistent poor performance designation.
From 1st January 2018, Cytogenomics External Quality Assessment Service (CEQAS) and UK National External Quality Assessment Service (UK NEQAS) for Molecular Genetics merged to become Genomics Quality Assessment (GenQA).