Therapeutic Drug Monitoring|
In transition to ISO /IEC 17043:2010
Antibiotic Assays Therapeutic Drug Monitoring (TDM)
PURPOSE OF PROGRAMME:
To assess a laboratory's ability to measure antimicrobial and antifungal concentrations using analytical methods pertaining to the analyte being tested
MATERIAL PROVIDED: Spiked pooled human serum non – reactive (1.0 ml volume)
DISTRIBUTIONS PER YEAR: 12
SAMPLES PER DISTRIBUTION: 1
FREQUENCY OF DISTRIBUTION: Monthly
PROGRAMME OF ANALYSIS:
Results entered online via the BQ web service. Open for 2weeks to enter results for Antimicrobials. Open 3 weeks for Antifungal results entry. Late results for overseas participants or extenuating circumstances are accepted via fax/e-mail.
Quantitative analysis. Results are scored against a consensus All Laboratory Trimmed Mean (ALTM) based upon results within 2SD of the untrimmed mean.
Laboratory Performance Monitoring over a rolling 6 month period based on three to six returns. Mean percentage error (m) over the last six distributions (that is, over six samples assayed over a six-monthly period) and the standard deviation (s) about that mean are calculated. Each laboratory is then assigned to a performance group (1-11) and a performance Score (of -1, 0, 1 or 2) A SCORE of 2 is acceptable performance over the six-month period. A SCORE of 0 or -1 indicates poor or very poor pe
METHOD PERFORMANCE is monitored monthly based on method trimmed mean, % SD, % CV. A result >30% away from the ALTM is classed as poor for that distribution and written to by the scheme organiser.
PERSISTENT POOR PERFORMANCE:
Twice a year (after March and September's distributions), the scheme conducts laboratory poor performance reviews. Any laboratory which has a MEAN+2SD value greater than 50.0 will flag as a poor performer ( a single distribution or methodological bias) or if they fail to return on >2 occassions within any 6-months).
The External Quality Assessment Scheme for Antibiotic Assay was founded in 1972 by Professor David Reeves at Southmead Hospital, Bristol. In 1985 the Service became known as the UK National External Quality Assessment Service for Antibiotic Assay. UK NEQAS AA is part of the University Hospitals Birmingham NHS Trust.