The NHS Knowledge Transfer Partnership (KTP) Programme

Webinar Event Coming Very Soon

Best Practice and Standardisation of Measurable Residual Disease Testing in Leukaemia

Date: Tuesday 4^th October 2022

Time: 09:15-15:45 (UK)

Objectives:

• To improve basic knowledge of molecular measurable residual disease (MRD) testing
• To share best practice for MRD testing
• To look at the current use of acute myeloid leukaemia (AML) MRD testing and assess what more can be done to reduce intra and inter laboratory variation

  Topics

• Overview of molecular measurable residual disease testing – history; quantitative reverse transcription PCR (RTqPCR), quantitative reverse transcription digital PCR (RTdPCR), next generation sequencing; disease specific use in leukaemia; future areas for development
• Nucleic acid metrology and its role in supporting standardization of MRD testing in leukaemia
• The role of digital PCR in standardisation
• The role of reference materials in precision medicine, traceability, levels of uptake, how they can improve diagnostics to benefit public health
• BCR::ABL1 in CML: The development of primary and secondary WHO reference panels, calibrants, EUTOS standardisation projects - lessons learned.
• Molecular AML MRD: markers (nuances e.g. transcript types); clinical use of markers, use in standard of care/clinical trials setting
• The different challenges of standardising molecular MRD testing in AML and CML
• Development of molecular AML MRD assays, validation, and standardisation
• European LeukaemiaNet MRD AML standardisation projects
• Development of EQA, initial results, future plans

Speakers

• Stuart Scott, UK NEQAS Leucocyte Immunophenotyping
• Dr Alec Morley, Department of Haematology and Genetic Pathology, Flinders University
• Dr Alison Devonshire, National Measurement Laboratory, LGC
• Dr Adam Corner, Digital Biology Group, Bio-Rad Laboratories
• Prof Nick Cross, Faculty of Medicine, University of Southampton
• Dr Helen White, Faculty of Medicine, University of Southampton
• Dr Leandro Lo-Cascio, National Institute of Biological Standards and Controls
• Dr Nicola Potter, Department of Medical & Molecular Genetics, King’s College
• Dr Katya Mokretar, Department of Medical & Molecular Genetics, King’s College
• Dr Richard Dillon, Department of Medical & Molecular Genetics, King’s College
• Prof Christian Thiede, University Hospital Carl Gustav Carus, Dresden University of Technology

This is a free-to-attend event. Click the green book now button to register your place on this webinar.