Myeloma clinical case scenarios
PURPOSE OF PROGRAMME:
Analysis and interpretation of recurrent abnormalities associated with myeloma: online interphase FISH analysis with supplementary tests as applicable, and/or fixed cell suspensions for interphase FISH, or DNA for array or NGS studies.
|Fixed cell suspension for FISH testing (various probes) extracted from Myeloma samples||Qualitative detection of absence/presence of abnormality using FISH or array.|
|FISH images online||Qualitative detection of absence/presence of abnormality using FISH or array.|
MATERIAL PROVIDED: Cells: fixed suspension, DNA in TE buffer, Images: FISH (Fluorescent In-situ Hybridisation), Images: G-banded chromosomes
DISTRIBUTIONS PER YEAR: 1
SAMPLES PER DISTRIBUTION: 2
FREQUENCY OF DISTRIBUTION: 1
PROGRAMME OF ANALYSIS:
Detection of recurrent abnormalities and/or testing of whole genome copy number changes and structural rearrangements.
Satisfactory/Poor. A non-submission is also given a poor performance.
PERSISTENT POOR PERFORMANCE:
This is defined as: a) Two poor performances in any haematology cytogenetic EQA in which the laboratory participates, over three or more distributions of material, within a 36 month rolling period; b) A poor performance within one year following a previous persistent poor performance designation.
From 1st January 2018, Cytogenomics External Quality Assessment Service (CEQAS) and UK National External Quality Assessment Service (UK NEQAS) for Molecular Genetics merged to become Genomics Quality Assessment (GenQA). Please click here for an overview of GenQA