Tumour Markers (CA Series)
UKAS accredited proficiency testing provider No. 7795
Diagnosis and management of malignant disease
PURPOSE OF PROGRAMME:
Oncology EQA scheme
|Breast Markers - CA153|
|Chromogranin A (Pilot analyte)||ng/mL and nmol/L|
|Gut Markers - CA199|
|Lung Markers - NSE|
|Neuron Specific Enolase (NSE)||µg/L|
|Ovarian Markers - CA125|
MATERIAL PROVIDED: Liquid format. Normal and pathological human serum
DISTRIBUTIONS PER YEAR: 6
SAMPLES PER DISTRIBUTION: 10 (2 x CA125, 2 x CA15-3, 2 x CA19-9, 2 x NSE, 2 x Chromogranin A)
FREQUENCY OF DISTRIBUTION: Every two months as outlined in the Distribution Schedule
PROGRAMME OF ANALYSIS:
Data entry is via the web for the submission of results. Data analysis is commenced 21 days after sample dispatch. Late returns are accepted and will contribute to the laboratory's cumulative performance statistics.
All Laboratory Trimmed Mean (ALTM) with truncation at 2SD, SD, and CV%. Reports also show method and manufacturer specific statistics. Individual laboratory performance is expressed in terms of MRBIS, SDBIS, and MRVIS. Because of marked differences in antigenic potency of some commercial kits, the Designated Value (DV) for calculation of VI is the Method Laboratory Trimmed Mean (MLTM). A minimum of four participants is required for the full analysis of the data set for any particular marker. Chosen Coefficient of Variation: CA125 and Ovarian markers 10% CA15-3 and Breast markers 12.5% CA19-9 and GI markers 12.5% NSE and Lung markers 12.5% Chromogranin A 12.5%
Laboratory performance is classified in terms of the MRVIS over a running analytical window of 6 Distributions (12 months).
PERSISTENT POOR PERFORMANCE:
Defined as being in the Poor Performance category for two or more successive Distributions.
Immunology, Immunochemistry & Allergy (IIA)
The External Quality Assessment Scheme for Immunology, Immunochemistry & Allergy (IIA) was founded in 1982 by Dr Anthony Milford Ward at Northern General Hospital, Sheffield. In 1982 the Service became known as the UK National External Quality Assessment Service for Immunology, Immunochemistry & Allergy. UK NEQAS IIA is part of the Sheffield Teaching Hospitals NHS Foundation Trust.